Latest BAKER BROS. ADVISORS LP Stock Portfolio
$7.97Billion
Equity Portfolio Value
Last Reported on: 15 May, 2024
About BAKER BROS. ADVISORS LP and it’s 13F Hedge Fund Stock Holdings
BAKER BROS. ADVISORS LP is a hedge fund based in NEW YORK, NY. On 24-Mar-2023, the fund reported that it had an AUM (Regulated Assets under Management) of $23.2 Billions. In it's latest 13F Holdings report, BAKER BROS. ADVISORS LP reported an equity portfolio of $8 Billions as of 31 Mar, 2024.
The top stock holdings of BAKER BROS. ADVISORS LP are INCY, BGNE, ACAD. The fund has invested 25.9% of it's portfolio in INCYTE CORPORATION and 20.7% of portfolio in BEIGENE, LTD.
The fund managers got completely rid off MIRATI THERAPEUTICS, INC. (MRTX), GRACELL BIOTECHNOLOGIES INC. (GRCL) and DAY ONE BIOPHARMACEUTICALS, INC. (DAWN) stocks. They significantly reduced their stock positions in PERSPECTIVE THERAPEUTICS, INC., ACHILLES THERAPEUTICS PLC (ACHL) and IMMUNOCORE HOLDINGS PLC (IMCR). BAKER BROS. ADVISORS LP opened new stock positions in FATE THERAPEUTICS, INC. (FATE), NEUMORA THERAPEUTICS, INC. and DYNE THERAPEUTICS, INC. (DYN). The fund showed a lot of confidence in some stocks as they added substantially to CELCUITY INC. (CELC), BICYCLE THERAPEUTICS PLC (BCYC) and XENCOR, INC. (XNCR).
The top stock holdings of BAKER BROS. ADVISORS LP are INCY, BGNE, ACAD. The fund has invested 25.9% of it's portfolio in INCYTE CORPORATION and 20.7% of portfolio in BEIGENE, LTD.
The fund managers got completely rid off MIRATI THERAPEUTICS, INC. (MRTX), GRACELL BIOTECHNOLOGIES INC. (GRCL) and DAY ONE BIOPHARMACEUTICALS, INC. (DAWN) stocks. They significantly reduced their stock positions in PERSPECTIVE THERAPEUTICS, INC., ACHILLES THERAPEUTICS PLC (ACHL) and IMMUNOCORE HOLDINGS PLC (IMCR). BAKER BROS. ADVISORS LP opened new stock positions in FATE THERAPEUTICS, INC. (FATE), NEUMORA THERAPEUTICS, INC. and DYNE THERAPEUTICS, INC. (DYN). The fund showed a lot of confidence in some stocks as they added substantially to CELCUITY INC. (CELC), BICYCLE THERAPEUTICS PLC (BCYC) and XENCOR, INC. (XNCR).
New Buys
| Ticker | $ Bought |
|---|---|
| FATE THERAPEUTICS, INC. | 13,345,400 |
| NEUMORA THERAPEUTICS, INC. | 8,715,450 |
| DYNE THERAPEUTICS, INC. | 8,091,150 |
| PRAXIS PRECISION MEDICINES, INC. | 8,026,140 |
| SAGE THERAPEUTICS, INC. | 7,631,250 |
| ALPINE IMMUNE SCIENCES, INC. | 3,233,750 |
| 4D MOLECULAR THERAPEUTICS, INC. | 3,186,000 |
| NEWAMSTERDAM PHARMA COMPANY N.V. | 2,289,960 |
New stocks bought by BAKER BROS. ADVISORS LP
Additions
| Ticker | % Inc. |
|---|---|
| CELCUITY INC. | 189 |
| BICYCLE THERAPEUTICS PLC | 176 |
| XENCOR, INC. | 122 |
| EDGEWISE THERAPEUTICS, INC. | 87.62 |
| STOKE THERAPEUTICS, INC. | 65.92 |
| REVOLUTION MEDICINES, INC. | 46.63 |
| DENALI THERAPEUTICS INC. | 43.13 |
| ABCELLERA BIOLOGICS INC. | 20.15 |
Additions to existing portfolio by BAKER BROS. ADVISORS LP
Reductions
| Ticker | % Reduced |
|---|---|
| PERSPECTIVE THERAPEUTICS, INC. | -98.04 |
| ACHILLES THERAPEUTICS PLC | -42.52 |
| IMMUNOCORE HOLDINGS PLC | -39.89 |
| OPTHEA LIMITED | -15.87 |
| SAGIMET BIOSCIENCES INC. | -5.12 |
| ROIVANT SCIENCES LTD. | -2.36 |
| ADAPTIMMUNE THERAPEUTICS PLC | -1.66 |
BAKER BROS. ADVISORS LP reduced stake in above stock
Sold off
| Ticker | $ Sold |
|---|---|
| INVITAE CORPORATION | -131,152,000 |
| INVITAE CORPORATION | -6,272,700 |
| MIRATI THERAPEUTICS, INC. | -242,135,000 |
| ATRECA, INC. | -287,430 |
| GRACELL BIOTECHNOLOGIES INC. | -20,883,200 |
| ARS PHARMACEUTICALS, INC. | -10,995,400 |
| INVITAE CORPORATION | -1,106,020 |
| DAY ONE BIOPHARMACEUTICALS, INC. | -14,600,000 |
BAKER BROS. ADVISORS LP got rid off the above stocks
Current Stock Holdings of BAKER BROS. ADVISORS LP
Last Reported on: 15 May, 2024| Ticker | Namesorted ascending | % Portfolio | Shares Held | $ Value | Type | % Change | Options |
|---|---|---|---|---|---|---|---|
| AADI | AADI BIOSCIENCE, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| ABCL | ABCELLERA BIOLOGICS INC. | 1.56 | 27,525,600 | 124,691,000 | ADDED | 20.15 | |
| ACAD | ACADIA PHARMACEUTICALS INC. | 9.94 | 42,864,600 | 792,567,000 | UNCHANGED | 0.00 | |
| ACHL | ACHILLES THERAPEUTICS PLC | 0.02 | 1,208,780 | 1,510,970 | REDUCED | -42.52 | |
| ADAP | ADAPTIMMUNE THERAPEUTICS PLC | 0.21 | 10,787,000 | 17,043,500 | REDUCED | -1.66 | |
| AKRO | AKERO THERAPEUTICS, INC. | 0.86 | 2,713,200 | 68,535,600 | ADDED | 14.56 | |
| ALGS | ALIGOS THERAPEUTICS, INC. | 0.03 | 2,076,400 | 2,034,870 | UNCHANGED | 0.00 | |
| ALPN | ALPINE IMMUNE SCIENCES, INC. | 0.04 | 81,578 | 3,233,750 | NEW | ||
| ARGX | ARGENX SE | 0.75 | 151,215 | 59,536,400 | UNCHANGED | 0.00 | |
| ATHA | ATHIRA PHARMA, INC. | 0.11 | 3,153,810 | 8,641,430 | UNCHANGED | 0.00 | |
| AVTE | AEROVATE THERAPEUTICS, INC. | 0.62 | 1,680,520 | 49,692,900 | UNCHANGED | 0.00 | |
| BCEL | ATRECA, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| BCRX | BIOCRYST PHARMACEUTICALS, INC. | 0.64 | 10,126,200 | 51,441,000 | UNCHANGED | 0.00 | |
| BCYC | BICYCLE THERAPEUTICS PLC | 1.54 | 4,942,820 | 123,076,000 | ADDED | 176 | |
| BGNE | BEIGENE, LTD. | 20.73 | 10,568,900 | 1,652,870,000 | UNCHANGED | 0.00 | |
| BMEA | BIOMEA FUSION, INC. | 0.40 | 2,108,950 | 31,528,800 | UNCHANGED | 0.00 | |
| CABA | CABALETTA BIO, INC. | 0.00 | 13,331 | 227,427 | UNCHANGED | 0.00 | |
| CELC | CELCUITY INC. | 0.42 | 1,552,480 | 33,533,500 | ADDED | 189 | |
| CERE | CEREVEL THERAPEUTICS HOLDINGS, INC. | 0.85 | 1,600,000 | 67,632,000 | UNCHANGED | 0.00 | |
| CERS | CERUS CORPORATION | 0.46 | 19,477,300 | 36,812,200 | UNCHANGED | 0.00 | |
| CLDX | CELLDEX THERAPEUTICS, INC. | 0.13 | 247,644 | 10,393,600 | UNCHANGED | 0.00 | |
| CMPX | COMPASS THERAPEUTICS, INC. | 0.04 | 1,557,630 | 3,084,110 | UNCHANGED | 0.00 | |
| DAWN | DAY ONE BIOPHARMACEUTICALS, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| DBVT | DBV TECHNOLOGIES S.A. | 0.14 | 14,614,300 | 10,947,500 | UNCHANGED | 0.00 | |
| DNLI | DENALI THERAPEUTICS INC. | 0.96 | 3,731,700 | 76,574,400 | ADDED | 43.13 | |
| DSGN | DESIGN THERAPEUTICS, INC. | 0.08 | 1,662,120 | 6,698,340 | ADDED | 10.81 | |
| DYN | DYNE THERAPEUTICS, INC. | 0.10 | 285,000 | 8,091,150 | NEW | ||
| EWTX | EDGEWISE THERAPEUTICS, INC. | 1.34 | 5,840,060 | 106,523,000 | ADDED | 87.62 | |
| FATE | FATE THERAPEUTICS, INC. | 0.17 | 1,818,180 | 13,345,400 | NEW | ||
| FDMT | 4D MOLECULAR THERAPEUTICS, INC. | 0.04 | 100,000 | 3,186,000 | NEW | ||
| FHTX | FOGHORN THERAPEUTICS INC. | 0.00 | 45,027 | 302,131 | UNCHANGED | 0.00 | |
| GBIO | GENERATION BIO CO. | 0.02 | 371,219 | 1,510,860 | NEW | ||
| GLUE | MONTE ROSA THERAPEUTICS, INC. | 0.44 | 4,916,100 | 34,658,500 | UNCHANGED | 0.00 | |
| GRCL | GRACELL BIOTECHNOLOGIES INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| HOOK | HOOKIPA PHARMA INC. | 0.07 | 8,128,150 | 5,787,240 | UNCHANGED | 0.00 | |
| IDYA | IDEAYA BIOSCIENCES, INC. | 0.58 | 1,062,120 | 46,606,000 | UNCHANGED | 0.00 | |
| IGMS | IGM BIOSCIENCES, INC. | 0.50 | 4,088,320 | 39,452,300 | ADDED | 10.76 | |
| IMCR | IMMUNOCORE HOLDINGS PLC | 1.24 | 1,515,320 | 98,495,700 | REDUCED | -39.89 | |
| IMTX | IMMATICS N.V. | 0.85 | 6,443,400 | 67,720,100 | ADDED | 10.35 | |
| IMVT | IMMUNOVANT, INC. | 0.17 | 425,009 | 13,732,000 | UNCHANGED | 0.00 | |
| INCY | INCYTE CORPORATION | 25.86 | 36,179,700 | 2,061,160,000 | ADDED | 0.00 | |
| INSM | INSMED INCORPORATED | 0.12 | 343,000 | 9,305,590 | UNCHANGED | 0.00 | |
| IPSC | CENTURY THERAPEUTICS, INC. | 0.04 | 797,460 | 3,333,380 | UNCHANGED | 0.00 | |
| KALA | KALA BIO, INC. | 0.03 | 266,613 | 2,124,910 | UNCHANGED | 0.00 | |
| KNSA | KINIKSA PHARMACEUTICALS, LTD. | 0.70 | 2,809,580 | 55,433,000 | UNCHANGED | 0.00 | |
| KOD | KODIAK SCIENCES INC. | 1.14 | 17,310,500 | 91,053,200 | UNCHANGED | 0.00 | |
| KRYS | KRYSTAL BIOTECH, INC. | 0.38 | 169,934 | 30,236,400 | UNCHANGED | 0.00 | |
| KYMR | KYMERA THERAPEUTICS, INC. | 3.02 | 5,995,930 | 241,036,000 | UNCHANGED | 0.00 | |
| LPTX | LEAP THERAPEUTICS, INC. | 0.04 | 1,172,180 | 3,117,990 | UNCHANGED | 0.00 | |
| MDGL | MADRIGAL PHARMACEUTICALS, INC. | 6.60 | 1,969,800 | 526,015,000 | UNCHANGED | 0.00 | |
| MIRM | MIRUM PHARMACEUTICALS, INC. | 0.06 | 190,476 | 4,784,760 | UNCHANGED | 0.00 | |
| MRSN | MERSANA THERAPEUTICS, INC. | 0.06 | 1,086,120 | 4,865,800 | UNCHANGED | 0.00 | |
| MRTX | MIRATI THERAPEUTICS, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| NAMS | NEWAMSTERDAM PHARMA COMPANY N.V. | 0.03 | 96,827 | 2,289,960 | NEW | ||
| NRIX | NURIX THERAPEUTICS, INC. | 0.72 | 3,882,120 | 57,067,200 | UNCHANGED | 0.00 | |
| NVTA | INVITAE CORPORATION | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| NVTA | INVITAE CORPORATION | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| NVTA | INVITAE CORPORATION | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| OPT | OPTHEA LIMITED | 0.11 | 2,177,830 | 8,950,860 | REDUCED | -15.87 | |
| PCVX | VAXCYTE, INC. | 0.04 | 48,885 | 3,339,330 | UNCHANGED | 0.00 | |
| PFE | PFIZER INC. | 0.01 | 35,000 | 971,250 | UNCHANGED | 0.00 | |
| PMVP | PMV PHARMACEUTICALS, INC. | 0.01 | 322,024 | 547,441 | UNCHANGED | 0.00 | |
| PRAX | PRAXIS PRECISION MEDICINES, INC. | 0.10 | 131,533 | 8,026,140 | NEW | ||
| PRAX | PRAXIS PRECISION MEDICINES, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| PRLD | PRELUDE THERAPEUTICS INC. | 0.60 | 10,123,800 | 47,986,900 | UNCHANGED | 0.00 | |
| RARE | ULTRAGENYX PHARMACEUTICAL INC. | 0.86 | 1,466,550 | 68,473,100 | UNCHANGED | 0.00 | |
| REPL | REPLIMUNE GROUP, INC. | 0.98 | 9,545,340 | 77,985,400 | UNCHANGED | 0.00 | |
| RLAY | RELAY THERAPEUTICS, INC. | 0.12 | 1,160,120 | 9,628,970 | UNCHANGED | 0.00 | |
| ROIV | ROIVANT SCIENCES LTD. | 0.98 | 7,413,830 | 78,141,800 | REDUCED | -2.36 | |
| RVMD | REVOLUTION MEDICINES, INC. | 3.05 | 7,549,250 | 243,312,000 | ADDED | 46.63 | |
| RYTM | RHYTHM PHARMACEUTICALS, INC. | 3.48 | 6,398,360 | 277,241,000 | UNCHANGED | 0.00 | |
| SAGE | SAGE THERAPEUTICS, INC. | 0.10 | 407,217 | 7,631,250 | NEW | ||
| SANA | SANA BIOTECHNOLOGY, INC. | 0.30 | 2,380,950 | 23,809,500 | ADDED | 19.05 | |
| SBTX | ARS PHARMACEUTICALS, INC. | 0.00 | 0.00 | 0.00 | SOLD OFF | -100 | |
| SERA | SERA PROGNOSTICS, INC. | 0.62 | 5,434,400 | 49,453,000 | UNCHANGED | 0.00 | |
| SRZN | SURROZEN, INC. | 0.00 | 833,333 | 25,167 | UNCHANGED | 0.00 | |
| STOK | STOKE THERAPEUTICS, INC. | 0.57 | 3,368,440 | 45,474,000 | ADDED | 65.92 | |
| TARA | PROTARA THERAPEUTICS, INC. | 0.01 | 199,671 | 800,681 | UNCHANGED | 0.00 | |
| TCRX | TSCAN THERAPEUTICS, INC. | 0.28 | 2,784,790 | 22,111,200 | UNCHANGED | 0.00 | |
| TLIS | TALIS BIOMEDICAL CORPORATION | 0.06 | 508,323 | 4,447,830 | UNCHANGED | 0.00 | |
| TNGX | TANGO THERAPEUTICS, INC. | 0.07 | 750,000 | 5,955,000 | UNCHANGED | 0.00 | |
| TRDA | ENTRADA THERAPEUTICS, INC. | 0.86 | 4,865,820 | 68,948,700 | UNCHANGED | 0.00 | |
| TSHA | TAYSHA GENE THERAPIES, INC. | 0.14 | 4,004,760 | 11,493,600 | UNCHANGED | 0.00 | |
| TSVT | 2SEVENTY BIO, INC. | 0.17 | 2,497,530 | 13,361,800 | UNCHANGED | 0.00 | |
| TYRA | TYRA BIOSCIENCES, INC. | 0.00 | 10,607 | 173,955 | UNCHANGED | 0.00 | |
| VERV | VERVE THERAPEUTICS, INC. | 0.28 | 1,691,530 | 22,463,500 | UNCHANGED | 0.00 | |
| VTVT | VTV THERAPEUTICS, INC. | 0.03 | 97,314 | 2,289,800 | NEW | ||
| XENE | XENON PHARMACEUTICALS INC. | 0.54 | 993,679 | 42,777,900 | UNCHANGED | 0.00 | |
| XNCR | XENCOR, INC. | 0.15 | 545,431 | 12,070,400 | ADDED | 122 | |
| NEUROGENE INC. | 0.29 | 456,015 | 23,211,200 | ADDED | 0.55 | ||
| NEUMORA THERAPEUTICS, INC. | 0.11 | 633,851 | 8,715,450 | NEW | |||
| SAGIMET BIOSCIENCES INC. | 0.09 | 1,381,900 | 7,489,890 | REDUCED | -5.12 | ||
| PRIME MEDICINE, INC. | 0.09 | 1,028,470 | 7,199,260 | UNCHANGED | 0.00 | ||
| ENLIVEN THERAPEUTICS, INC. | 0.03 | 114,833 | 2,019,910 | NEW | |||
| MURAL ONCOLOGY PLC | 0.01 | 222,503 | 1,088,040 | NEW | |||
| PERSPECTIVE THERAPEUTICS, INC. | 0.00 | 149,787 | 178,247 | REDUCED | -98.04 | ||
| ACRIVON THERAPEUTICS, INC. | 0.00 | 52,885 | 378,128 | NEW |